Sleep disorders as core symptoms of depression

Dialogues Clin Neurosci. 2008;10:329-336.

Links between sleep and depression are strong. About three quarters of depressed patients have insomnia symptoms, and hypersomnia is present in about 40% of young depressed adults and 10% of older patients, with a preponderance in females. The symptoms cause huge distress, have a major impact on quality of life, and are a strong risk factor for suicide. As well as the subjective experience of sleep symptoms, there are well-documented changes in objective sleep architecture in depression. Mechanisms of sleep regulation and how they might be disturbed in depression are discussed. The sleep symptoms are often unresolved by treatment, and confer a greater risk of relapse and recurrence. Epidemiological studies have pointed out that insomnia in nondepressed subjects is a risk factor for later development of depression. There is therefore a need for more successful management of sleep disturbance in depression, in order to improve quality of life in these patients and reduce an important factor in depressive relapse and recurrence.

Author Affiliations: 
Psychopharmacology Unit, University of Bristol, UK (David Nutt) 
Address for correspondence: 
david.j.nutt@bris.ac.uk 
Abbreviations and acronyms: 
5-HT
serotonin
REM
rapid eye movement
SSRI
selective serotonin reuptake inhibitor
SWA
slow-wave actvity
SWS
slow-wave sleep
 

There is a very strong association between sleep disturbance and major depression, lite link between the two is so fundamental that some researchers have suggested that a diagnosis of depression in the absence of sleep complaints should be made with caution. [1] Sleep disturbance is one of the key symptoms of the disease, may be the reason that depressed patients first seek help, and is one of the few proven risk factors for suicide. [2] If sleep problems remain after other symptoms are ameliorated, there is a significantly increased risk of relapse and recurrence. Another aspect of the association is the remarkable, if paradoxical, temporary improvement in mood seen after total sleep deprivation in a high proportion of depressed patients.

Incidence of sleep symptoms in depression

Symptoms of disturbed night-time sleep in people with depression have been described extensively in both clinical and epidemiological studies. In clinical samples, difficulty in initiating or maintaining sleep (including earlymorning wakening) or both have been reported in about three quarters of all depressed patients. [3],[4] In epidemiological samples examining insomnia symptoms and depression, sleep symptoms occurred in 50% to 60% in a sample of young adults aged 21 to 30. [5] In a UK population sample (n=8580), [6] the incidence of insomnia symptoms in a wide age range of patients with depression increased with age. Overall, 83% of depressed patients had at least one insomnia symptom, compared with 36% who did not have depression. This varied from 77% in the 16-to-24-year age group to 90% in the 55-to-64-year age group. When the authors looked at the value of sleep symptoms as a screening aid for depression, the proportion of participants with depression who reported symptoms of insomnia sufficient to warrant a diagnosis of insomnia (DSM-IV) was 41%, and the proportion without depression and without a diagnosis was 96%. This supports the statement mentioned above that diagnosing depression without sleep complaints needs care.

Hypersomnia is less common, and tends to be a feature of atypical depression, and more prevalent in the young, with about 40% of patients under 30 and 10% of those in their 50s experiencing the symptom, [7] and a higher incidence in females of all ages. Some patients experience both insomnia and hypersomnia during the same depressive episode.

• Insomnia is common in depression • Sleep arhitecure is
and may be the presenting complaint abnormal in depression
• Sleep disturbance may predict • Antidepressants change
treatment outcome, including relapse sleep architecure in
and recurrence the opposite direction
• Sleep manipulation alters mood
Table I. Sleep and depression are strongly linked.

Distress and quality of life

Disturbed sleep is a very distressing symptom which has huge impact on quality of life in depressed patients. [8] We surveyed the views of patients with depression about their symptoms and associated sleep difficulties. [9] In this study, 2800 members of Depression Alliance, a UK-based charity for people with depression, were sent a postal questionnaire. Respondents were asked if, when they are depressed, they suffer from sleep difficulties (Table II).

Some 97% reported sleep difficulties during depression and 59% of these indicated that poor sleep significantly affected their quality of life. The majority believed their sleep difficulties started at the same time as their depression. About, two thirds had sought extra treatment - such as prescribed sleeping pills, over-the-counter sleeping aids, and extra visits to their doctor - for their sleep problems. In another recent study, [10] depressed patients reported significantly poorer perceptions of sleep quality and poorer perceptions of life quality and mood than the control group, even though estimates of sleep disturbance were similar, litis may indicate that depressed individuals experience more "sleep distress" than healthy individuals.

Nature of sleep and daytime symptoms %
Sleep disturbance symptoms (n=496)
Any 97
i) I can't get off to sleep 58
ii) I keep waking up in the night 59
iii) I wake early ana can't get back to sleep 61
iv) I sleep for too long 31
Insomnia only (i, ii and/or iii) 69
Hypersomnia only (iv) 10
Mixed insomnia/hypersomnia 21
Associated daytime symptoms (n=491) 99
I can't concentrate 81
I feel exhausted and lethargic 80
I have no energy 77
I feel very sleepy 41
I nap during the day 40
Extra treatment souabt (n=341) 69
Prescribed sleeping pills 48
Over-the-counter sleeping aids 29
Extra visits to the doctor 24
Effect on QOL (n=495)
Not at all 2
A little 10
Moderately 29
A lot 35
Very much 24
Onset of sleep problems (n=483)
A long time before my depression 16
About the same time as my depression 68
Table II. Sleep disturbance symptoms: nature, onset, effect on quality of life (QOL), and further treatment sought. [9]

Physiological findings in depression

As well as the distressing symptoms of sleep disturbance experienced by patients, changes in objective sleep architecture arc well-documented in depression. [11] Compared with normal controls, sleep continuity of depressed subjects is often impaired, with increased wakefulness (more frequent, and longer periods of wakefulness), and reduced sleep efficiency. Sleep onset latency is significantly increased and total sleep time reduced. Rapid eye movement (REM) latency is often shortened, and the duration of the first REM period is increased (Figure 1). The number of eye movements in REM (REM density) is also increased.

Slow-wave activity (SWA) seen on the electroencephalogram (ERG) during non-RRM sleep is a marker of the homeostatic drive to sleep; thus, the amount of SWA is greatest in the first sleep cycle when sleep propensity is high, and gradually diminishes in subsequent cycles as sleep debt is made up and sleep drive diminished. The total amount of SWS is often decreased in depression, compared with normal controls. [11] This reduction may be related to decreased regional cerebral blood flow seen in the orbitofrontal and anterior cingulate cortex during slow-wave sleep (SWS) in imaging studies, [12] and it may be a consequence of the abnormalities in this area described in depression. [13] In addition, reduction in SWS can reflect fragmented sleep in general, such as is seen in depression.

Another anomaly seen in depressed patients is that the normal pattern of SWA decreasing from the first to the last NREM episode is disrupted, with less of a decrease in SWA occurring from the first to the second episode in depressed patients [14],[15] (Figure 2). This is sometimes expressed as a lower delta sleep ratio (DSR) that is the quotient of SWA in the first to the second non-RRM period of sleep.

Some of these sleep architecture abnormalities are present during full clinical remission, and also appear to be associated with an increased risk for relapse.[16],​[17],​[18] High REM density and reduced SWS in the first cycle were also present in first-degree relatives of depressed patients in the Munich Vulnerability Study on Affective Disorders, measured on two occasions 4 years apart, [19] and in a more recent study, REM density predicted those who had subsequently developed a major depressive episode. [20]

Figure 1. Hypnograms from a normal subject (upper) and a depressed patient (lower). The depressed patient has a shortened REM sleep latency, very little slow-wave (stages 3 and 4) sleep, particularly in the first sleep cycle, more awakening, and a long period of waking at about 0430.
Figure 2. Evolution of slow-wave activity over the night in a normal subject (upper) and a depressed patient (lower). In the normal subject the amount of slow-wave activity is high in the first nonREM period, then diminishes over the night. In the depressed patient, the highest activity is in the second non-REM period.

Mechanisms of sleep regulation and disturbances in depression

Research over the past 25 years has revealed that the sleep-wake cycle is regulated by two separate but interacting processes, [21] the circadian (C) process and the homeostatic (S), or recovery process.

The C process is that which regulates the daily rhythms of the body and brain. Circadian (24-h) patterns of activity arc found in many organs and cells, and the main circadian pacemaker is found in a group of cells in the suprachiasmatic nucleus (SCN) of the hypothalamus. These cells provide an oscillatory pattern of activity which drives rhythms such as sleep-wake activity, hormone release, liver function, etc. This drive from the SCN is innate, self-sustaining, and independent of tiredness or amount of sleep. It is affected markedly by light and to some extent by temperature. Bright light in the evening will delay the clock, and bright light in the morning is necessary to synchronize the clock to a 24-hour rhythm; in constant light or darkness the cycle length is about 24.3 h. All animals have such a clock, and the period and timing appear to be dependent on particular genes, which are similar in fruit flies and mammals.

The drive to sleep from the circadian clock in normal sleepers starts to increase slowly at about 11 pm and gradually reaches a peak at about 4 am. This provides a sleeppromoting process which continues into mid-morning and then provides a wakefulness-promoting process during the day. The timing of REM sleep is linked to the circadian rhythm, closely mirroring the core temperature. Thus, the maximum propensity for REM sleep is usually after the nadir of core temperature, around 6 am, and it is less likely to occur during an afternoon and evening nap. [21]

The homeostatic or recovery drive to sleep (the S process) is wake-dependent, ie, it increases in proportion to the amount of time since last sleep. Its usual maximum is at about 11 pm, or about 16 hours after waking up in the morning, and then decreases during sleep, with a minimum at natural waking in the morning. When sleep has been shorter than usual there is a “sleep debt” which leads to an increase in the S process - this works to ensure that the debt is made up at the next sleep period, by accelerating the time to sleep and possibly by increasing sleep depth and duration.

These two processes interact to promote the onset of sleep when both are high (at the usual bedtime), and maintain sleep when the C process is high and the S process is declining (in the early hours of the morning). SWA (see above) is a marker of the homeostatic drive to sleep; thus, the amount of SWA is greatest in the first sleep cycle when sleep propensity is high, and gradually diminishes in subsequent cycles as sleep debt is made up and sleep drive diminished.

Sleep abnormalities in depression, both subjective and objective, point to a disruption in both homeostatic and circadian drives to sleep. A frequently occurring symptom is taking a long time to initiate sleep, [3] which is common to some other psychiatric conditions, particularly generalized anxiety disorder. [23] It may be that general hyperarousal, or psychic anxiety, which is present in about 80% of depressed patients, may be a contributory factor in this early insomnia. The alteration in timing or evolution of SWA may be thought of as a disruption in the normal S process, resulting in a decreased pressure to sleep. This hypothesis has never been tested properly in depressed patients, although its validity may be supported by the effects of sleep deprivation (see below). In addition, effective treatment with antidepressant drugs tends to restore the profile of SWA towards normal, [23] but it is difficult to disentangle these effects on SWA from those on REM sleep. [14]

In contrast, alterations in REM latency, increase in waking and stage 1 sleep, and waking early point to the C process being affected; in depression patients would have an earlier onset of key sleep rhythms. Whether the circadian rhythm disruption is a cause, a consequence, or a comorbid condition of depression is the subject of much research at present as the underlying genetic control of the mammalian clock is becoming clearer, and investigation of clock genes in depression more common. Some interesting data has emerged linking some of these genes with sleep in bipolar disorder [25] and with the response of insomnia in depression to treatment with antidepressants [26] ; however, there is little as yet which clarifies the relationship between circadian genes and sleep in unipolar depression. Another theory relates to deficiencies in key neurotransmitters such as serotonin (5-HT), noradrenaline, or acetylcholine leading to phase advance of sleep rhythms in depression.

Evidence for both S and C processes being implicated in depression is contained in the phenomenon of total sleep deprivation improving mood the next day in major depression, which has been known and used for many years. [27] This is an extension of the well-known feature seen in many patients with severe depression that mood is worse in the mornings and gradually improves during the day, to the point that it can be in the normal range just before bed - only to revert back to depression during sleep. However, keeping patients awake all night is difficult to perform, and once they are allowed uninterrupted sleep all the beneficial effects of sleep deprivation disappear. Recent, research has refined the methods of manipulation of sleep and circadian rhythm to maximize its effects on mood by bringing the sleep period forward, [27] and there have been several strategies proposed to prolong the therapeutic effect such as adding drug interventions and strictly controlling the amount and type of sleep allowed in the following days. [28],[29] It can be argued that this intervention works to increase the pressure for sleep (homeostatic process) and on basic circadian function in the brain, supporting a “phase advance” of circadian rhythm in depression which is corrected by sleep manipulation. Further evidence is gained from studies showing that those patients who respond to sleep deprivation and to light treatment are those in whom phase advance has been demonstrated by actimetry (a technique which measures sleep-wake cycles using movement sensors worn for many weeks on the wrist). [30]

There is evidence from animal studies of an immediate increase in 5-HT, noradrenaline, and dopamine function in rat brain after sleep deprivation. [31] Ncuroimaging studies provide some evidence that in depressed patients, the metabolic hyperactivity seen in the anterior cingulate in depression is corrected by sleep deprivation. [32],[33] Thus the effects of sleep deprivation may be mediated via multiple brain systems.

Sleep in depressed patients may be more sensitive to life events which disrupt daily rhythms. Haynes et al3“ rated these events in a group of depressed patients and measured sleep disruption by actigraphy. Depressed patients who had experienced social rhythm-disrupting events, for instance overseas travel, being fired from a full-time job without immediately starting another, starting full-time college, or marital separation, had much more wakefulness during the night compared with those patients without these events, and this difference was not evident in normal controls.

Increased risk of depression in insomnia

The National Institute of Mental Health Epidemiologic Catchment Area study 20 years ago interviewed 7954 adults on two occasions a year apart, and this study first highlighted the strong association between sleep disturbance and subsequent depression. They found that 14% of those who had insomnia at the first interview had developed new major depression a year later. [35] This data has been augmented by several more recent reports of increased risk. Brcslau ct al, [5] in a survey of 1200 young adults in Michigan, found that the odds ratio of new depression in was 4 times increased in those subjects who had insomnia 3 years earlier, and in a questionnaire survey of adults over 18 in the UK there was a 3-fold increased risk of new depression if subjects had reported one sleep problem occurring “on most nights” a year earlier. [36] Doctors in a prospective study who had complained of insomnia during medical school in the 1950s and 1960s were twice as likely to have developed depression at follow-up in 1990s. [37]

It is apparent that sleep problems often appear before other depression symptoms, [38] and that subjective sleep quality worsens before onset of an episode in recurrent depression. [39]

Residual insomnia: relapse and recurrence

There is much evidence that effective antidepressant treatments can successfully elicit significant response in depression, but is much less evidence that effective treatment fully addresses the problem of sleep disturbance. Persistent insomnia is one of the most common residual symptoms in patients with incomplete remission: [40] This presents a problem, given the fact that residual insomnia confers greater risk of subsequent depression: in a study of “remitted” patients maintained on a selective serotonin reuptake inhibotor (SSRI) and psychotherapy, [41] subjective sleep problems and anxiety were each found to be predictors of early recurrence. The origin of these residual symptoms of insomnia is probably multifactorial, reflecting ongoing functional brain abnormalities as well as adverse effects of some drug treatments, for example SSRIs, particularly fluoxetine, can lead to insomnia.

Implications for treatment

Anomalies in sleep architecture in depression are linked with treatment outcome; for instance they may predict poor response to cognitive behavioral therapy (CBT) [42] and interpersonal therapy, [43] and more patients experience a recurrence of depression after successful CBT treatment if they have an abnormal sleep profile. [42] Response to antidepressant drug treatment is not predicted by sleep EEG abnormalities; however, placebo nonresponse is more likely in those patients with an abnormal sleep profile. [44]

Selective serotonergic drugs are the present first-line therapy for depression, and there is much evidence for the involvement of 5-HT in the pathogenesis of both depression and sleep disturbance. For instance, rapid tryptophan depletion, which reduces brain 5-HT function, results in a temporary return of depressive symptoms in recovered depressed patients, [45] and a reduction in REM latency. [47] SSRIs which increase 5-HT function increase REM latency, and reduce REM sleep. [47] However, although SSRIs, scrotonin-norepincphrinc reuptake inhibitors (SNRIs), and venlafaxine are effective and widely used, they may worsen sleep disturbance early in treatment [48],[49] and may leave residual sleep symptoms once mood is improved. [50] Benzodiazepine and Z-drug hypnotics (nonbenzodiazepine hypnotics, such as Zolpidem and zopi clone) are often required to deal with these adverse effects, which can lead to problems with dependence and withdrawal. However, in a study in which eszopiclone was added to fluoxetine in depressed patients [51] there were significant beneficial effects, even in depressive symptoms other than insomnia items.

Some antidepressants can have a beneficial effect on sleep. These include mianserin, trazodone, nefazodone, and mirtazapine, as well as the older tricyclic antidepressants. The mechanisms underlying this are complex and relate to interactions (blockade) of certain neurotransmitter receptors - with significant 5-HT antagonist properties being a common theme - though antagonism at histamine H1 and noradrenaline α1 receptors also plays a part for some of these drugs.

In conclusion

Subjective and objective sleep disturbance in depression is prevalent, distressing, and often unresolved by treatment. It indicates significant alterations in brain neurotransmitter function, as well as leading to significant impairments in quality of life and further treatment-seeking by sufferers, so increasing the burden on health care services. There is therefore a need for more successful management of sleep disturbance in depression, in order to improve quality of life in these patients and reduce an important factor in depressive relapse and recurrence.

REFERENCES
1. Jindal RD, Thase ME Treatment of insomnia associated with clinical depression. Sleep Med Rev. 2004;8:19-30 [ Pub Med ]
2. Agargun MY, Kara H, Solinaz M Sleep disturbances and suicidal behavior in patients with major depression. J Clin Psychiatry. 1997;58:249-251 [ Pub Med ]
3. Hamilton M Frequency of symptoms in melancholia (depressive illness). Br J Psychiatry. 1989;154:201-206 [ Pub Med ]
4. Yates WR, Mitchell J, John RA, et al Clinical features of depression in outpatients with and without co-occurring general medical conditions in STAR*D: confirmatory analysis. Prim Care Companion J Clin Psychiatry. 2007;9:7-15 [ Pub Med ]
5. Breslau N, Roth T, Rosenthal L, Andreski P Sleep disturbance and psychiatric disorders: a longitudinal epidemiological study of young adults. Biol Psychiatry. 1996;39:411-418 [ Pub Med ]
6. Stewart R, Besset A, Bebbington P, et al Insomnia comorbidity and impact and hypnotic use by age group in a national survey population aged 16 to 74 years. Sleep. 2006;29:1391-1397 [ Pub Med ]
7. Posternak MA, Zimmerman M Symptoms of atypical depression. Psychiatry Res. 2001;104:175-181 [ Pub Med ]
8. Katz DA, McHomey CA The relationship between insomnia and health-related quality of life in patients with chronic illness. J Fam Pract. 2002;51:229-235 [ Pub Med ]
9. Paterson LM, Nutt DJ, Wilson SJ NAPSAQ 1: NAtional Patient Sleep Assessment Questionnaire in depression. intJ Psychiatry Clin Pract. 2008. In press.
10. Mayers AG, Van Hooff JC, Baldwin DS Quantifying subjective assessment of sleep and life-quality in antidepressant-treated depressed patients. Hum Psychopharmacol. 2003;18:21-27 [ Pub Med ]
11. Benca RM, Obermeyer WH, Thisted RA, Gillin JC Sleep and psychiatric disorders: a meta-analysis. Arch Gen Psych. 1992;49:651-670 [ Pub Med ]
12. Maquet P, Degueldre C, Delfiore G, et al Functional neuroanatomy of human slow wave sleep. J Neurosci. 1997;17:2807-2812 [ Pub Med ]
13. Drevets WC Orbitofrontal cortex function and structure in depression. Ann N Y Acad Sci. 2007;1121:499-527 [ Pub Med ]
14. Argyropoulos SV, Wilson SJ Sleep disturbances in depression and the effects of antidepressants. Int Rev Psychiatry. 2005;17:237-245 [ Pub Med ]
15. Armitage R Sleep and circadian rhythms in mood disorders. Acta Psychiatr Scand. 2007;(suppl):104-115 [ Pub Med ]
16. Giles D, Jarrett RB, Roffwarg HP, Rush AJ Reduced rapid eye moveme latency: a predictor of recurrence in depression. Neuropsychopharmacology. 1987;1:33-39 [ Pub Med ]
17. Steiger A, Holsboer F Nocturnal secretion of prolactin and Cortisol and the sleep EEG in patients with major endogenous depression during an acute episode and after full remission. Psychiatry Res. 1997;72:81-88 [ Pub Med ]
18. Rush AJ, Erman MK, Giles DE, et al Polysomnographic findings in recently drug-free and clinically remitted depressed patients. Arch Gen Psychiatry. 1986;43:878-884 [ Pub Med ]
19. Modell S, Ising M, Holsboer F, Lauer CJ The Munich Vulnerability Study on Affective Disorders: stability of polysomnographic findings over time. Biol Psychiatry. 2002;52:430-437 [ Pub Med ]
20. Modell S, Lauer CJ Rapid eye movement (REM) sleep: an endophenotype for depression. Curr Psychiatry Rep. 2007;9:480-485 [ Pub Med ]
21. Borbely AA A two-process model of sleep regulation. Hum Neurobiol. 1982;1:195-204 [ Pub Med ]
22. Dijk DJ, von Schantz M Timing and consolidation of human sleep, wakefulness, and performance by a symphony of oscillators. J Biol Rhythms. 2005;20:279-290 [ Pub Med ]
23. Nutt DJ Neurobiological mechanisms in generalized anxiety disorder. J Clin Psychiatry. 2001;62 Suppl 11:22-27 [ Pub Med ]
24. Jindal RD, Friedman ES, Berman SR, Fasiczka AL, Howland RH, Thase ME Effects of sertraline on sleep architecture in patients with depression. J Clin Psychopharmacol. 2003;23:540-548 [ Pub Med ]
25. Benedetti F, Dallaspezia S, Fulgosi MC, et al Actimetric evidence that CLOCK 3111 T/C SNP influences sleep and activity patterns in patients affected by bipolar depression. Am J Med Genet B Neuropsychiatr Genet. 2007;144:631-635 [ Pub Med ]
26. Serretti A, Cusin C, Benedetti F, et al Insomnia improvement during antidepressant treatment and CLOCK gene polymorphism. Am J Med Genet B Neuropsychiatr Genet. 2005;137:36-39 [ Pub Med ]
27. Wirz-Justice A, van den Hoofdakker RH Sleep deprivation in depression: what do we know, where do we go?. Biol Psychiatry. 1999;46:445-453 [ Pub Med ]
28. Giedke H The usefulness of therapeutic sleep deprivation in depression. J Affect Disord. 2004;78:85-86 [ Pub Med ]
29. Hemmeter U, Hatzinger M, Brand S, Holsboer-Trachsler E Effect of flumazenil-augmentation on microsleep and mood in depressed patients during partial sleep deprivation. J Psychiatr Res. 2007;41:876-884 [ Pub Med ]
30. Benedetti F, Dallaspezia S, Fulgosi MC, Barbini B, Colombo C, Smeraldi E Phase advance is an actimetric correlate of antidepressant response to sleep deprivation and light therapy in bipolar depression. Chronobiol int. 2007;24:921-937 [ Pub Med ]
31. Farooqui SM, Brock JW, Zhou J Changes in monoamines and their metabolite concentrations in REM sleep-deprived rat forebrain nuclei. Pharmacol Biochem Behav. 1996;54:385-391 [ Pub Med ]
32. Wu JC, Gillin JC, Buchsbaum MS, et al Sleep deprivation PET correlations of Hamilton symptom improvement ratings with changes in relative glucose metabolism in patients with depression. J Affect Disord. 2008;107:181-186 [ Pub Med ]
33. Smith GS, Reynolds CF, III , Houck PR, et al Glucose metabolic response to total sleep deprivation, recovery sleep, and acute antidepressant treatment as functional neuroanatomic correlates of treatment outcome in geriatric depression. Am J Geriatr Psychiatry. 2002;10:561-567 [ Pub Med ]
34. Haynes PL, McQuaid JR, Ancoli-lsrael S, Martin JL Disrupting life events and the sleep-wake cycle in depression. Psychol Med. 2006;36:1363-1373 [ Pub Med ]
35. Ford DE, Kamerow DB Epidemiological study of sleep disturbances and psychaitric disorders: an opportunity for prevention?. JAMA. 1989;262:1479-1484 [ Pub Med ]
36. Morphy H, Dunn KM, Lewis M, Boardman HF, Croft PR Epidemiology of insomnia: a longitudinal study in a UK population. Sleep. 2007;30:274-280 [ Pub Med ]
37. Chang PP, Ford DE, Mead LA, Cooper-Patrick L, Klag MJ Insomnia in young men and subsequent depression. The Johns Hopkins Precursors Study. Am J Epidemiol. 1997;146:105-114 [ Pub Med ]
38. Ohayon MM, Roth T Place of chronic insomnia in the course of depressive and anxiety disorders. J Psychiatr Res. 2003;37:9-15 [ Pub Med ]
39. Perlis ML, Giles DE, Buysse DJ, Tu X, Kupfer DJ Self-reported sleep disturbance as a prodromal symptom in recurrent depression. J Affect Disord. 1997;42:209-212 [ Pub Med ]
40. Carney CE, Segal ZV, Edinger JD, Krystal AD A comparison of rates of residual insomnia symptoms following pharmacotherapy or cognitivebehavioral therapy for major depressive disorder. J Clin Psychiatry. 2007;68:254-260 [ Pub Med ]
41. Dombrovski AY, Mulsant BH, Houck PR, et al Residual symptoms and recurrence during maintenance treatment of late-life depression. J Affect Disord. 2007;103:77-82 [ Pub Med ]
42. Thase ME, Simons AD, Reynolds CF, III Abnormal electroencephalographic sleep profiles in major depression: association with response to cognitive behavior therapy. Arch Gen Psychiatry. 1996;53:99-108 [ Pub Med ]
43. Thase ME, Buysse DJ, Frank E, et al Which depressed patients will respond to interpersonal psychotherapy? The role of abnormal EEG sleep profiles. Am J Psychiatry. 1997;154:502-509 [ Pub Med ]
44. Heiligenstein JH, Faries DE, Rush AJ, et al Latency to rapid eye movement sleep as a predictor of treatment response to fluoxetine and placebo in nonpsychotic depressed outpatients. Psych Res. 1994;52:327-339 [ Pub Med ]
45. Delgado PL, Price LH, Miller HL, et al Serotonin and the neurobiology of depression: effects of tryptophan depletion. Arch Gen Psychiatry. 1994;51:865-874 [ Pub Med ]
46. Moore PM, Gillin C, Bhatti T, et al Rapid tryptophan depletion, sleep electroencephalogram, and mood in men with remitted depression on serotonin reuptake inhibitors. Arch Gen Psychiatry. 1998;55:534-539 [ Pub Med ]
47. Wilson S, Argyropoulos S Antidepressants and sleep: a qualitative review of the literature. Drugs. 2005;65:927-947 [ Pub Med ]
48. Hicks JA, Argyropoulos SV, Rich AS, et al Randomised controlled study of sleep after nefazodone or paroxetine treatment in out-patients with depression. Br J Psychiatry. 2002;180:528-535 [ Pub Med ]
49. Diaz-Martinez A, Benassinni O, Ontiveros A, et al A randomized, openlabel comparison of venlafaxine and fluoxetine in depressed outpatients. Clin Ther. 1998;20:467-476 [ Pub Med ]
50. Nelson JC, Portera L, Leon AC Residual symptoms in depressed patients after treatment with fluoxetine or reboxetine. J Clin Psychiatry. 2005;66:1409-1414 [ Pub Med ]
51. Fava M, McCall WV, Krystal A, et al Eszopiclone co-administered with fluoxetine in patients with insomnia coexisting with major depressive disorder. Biol Psychiatry. 2006;59:1052-1060 [ Pub Med ]